Tsutomu Takeuchi Selected Research

Methotrexate (Mexate)

12/2023	Prevention of Radiographic Progression in Higher-Risk Patients with Rheumatoid Arthritis Using Filgotinib in Phase III Studies: Narrative Review of Post Hoc Analyses.
11/2023	Malignancy in the Upadacitinib Clinical Trials for Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Non-radiographic Axial Spondyloarthritis.
11/2023	Correction: Filgotinib Modulates Inflammation-Associated Peripheral Blood Protein Biomarkers in Adults with Active Rheumatoid Arthritis and Prior Inadequate Response to Methotrexate.
11/2023	Population Pharmacokinetics of Ozoralizumab in Patients with Rheumatoid Arthritis.
10/2023	Filgotinib Modulates Inflammation-Associated Peripheral Blood Protein Biomarkers in Adults with Active Rheumatoid Arthritis and Prior Inadequate Response to Methotrexate.
8/2023	Efficacy and safety of the anti-TNF multivalent NANOBODY® compound ozoralizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: A 52-week result of a Phase II/III study (OHZORA trial).
8/2023	Efficacy and safety of anti-TNF multivalent NANOBODY® compound 'ozoralizumab' without methotrexate co-administration in patients with active rheumatoid arthritis: A 52-week result of phase III, randomised, open-label trial (NATSUZORA trial).
7/2023	Long-term safety and efficacy of filgotinib treatment for rheumatoid arthritis in Japanese patients naïve to MTX treatment (FINCH 3).
7/2023	Efficacy and tolerability of subcutaneously administered methotrexate including dose escalation in long-term treatment of rheumatoid arthritis in a Japanese population.
6/2023	Immunosuppressive therapy and humoral response to third mRNA COVID-19 vaccination with a six-month interval in rheumatic disease patients.

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Tsutomu Takeuchi Research Topics

Disease

294	Rheumatoid Arthritis 04/2024 - 06/2003
51	Infections 11/2023 - 08/2002
25	Systemic Lupus Erythematosus (Libman-Sacks Disease) 02/2024 - 09/2003
23	Immunoglobulin G4-Related Disease 01/2023 - 01/2012
21	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2022 - 09/2005
19	Herpes Zoster 09/2023 - 01/2016
17	Inflammation (Inflammations) 01/2024 - 08/2003
17	Necrosis 12/2023 - 07/2011
17	Rheumatic Diseases (Rheumatism) 06/2023 - 01/2007
14	Neoplasms (Cancer) 11/2023 - 12/2002
14	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 08/2005
12	Adult-Onset Still's Disease 03/2024 - 03/2012
12	Pain (Aches) 12/2023 - 05/2012
12	Arthritis (Polyarthritis) 09/2023 - 01/2006
11	Lupus Nephritis 02/2024 - 01/2007
9	Drug-Related Side Effects and Adverse Reactions 02/2024 - 11/2010
9	Fever (Fevers) 05/2021 - 09/2005
9	Cysts 06/2012 - 09/2002
8	Systemic Scleroderma (Systemic Sclerosis) 01/2024 - 01/2007
8	Vasculitis (Vasculitides) 11/2023 - 01/2021
8	COVID-19 07/2023 - 01/2021
7	Lymphoproliferative Disorders (Lymphoproliferative Disorder) 11/2023 - 02/2007
7	Pneumonia (Pneumonitis) 01/2021 - 01/2007
7	Opportunistic Infections (Opportunistic Infection) 01/2021 - 01/2005
6	Fatigue 01/2024 - 01/2017
6	Disease Progression 07/2023 - 12/2017
6	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 01/2023 - 08/2017
6	Connective Tissue Diseases (Connective Tissue Disease) 01/2022 - 03/2013
6	Polymyalgia Rheumatica (Rhizomelic Pseudopolyarthritis) 10/2021 - 01/2015
6	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 11/2012 - 01/2007
5	Chronic Disease (Chronic Diseases) 12/2023 - 03/2013
5	Ankylosing Spondylitis 11/2023 - 08/2017
5	Psoriatic Arthritis 11/2023 - 08/2017
5	Ulcerative Colitis 10/2023 - 01/2017
5	Giant Cell Arteritis (Horton Disease) 01/2023 - 01/2020
5	Myositis (Idiopathic Inflammatory Myopathies) 01/2021 - 09/2005
5	Nasopharyngitis 01/2019 - 06/2016
5	Arthralgia (Joint Pain) 11/2018 - 07/2011
5	Amebiasis (Amoebiasis) 02/2006 - 08/2003
4	Crohn Disease (Crohn's Disease) 10/2023 - 01/2015
4	Takayasu Arteritis (Arteritis, Takayasu's) 01/2023 - 01/2020

Drug/Important Bio-Agent (IBA)

98	Methotrexate (Mexate)FDA LinkGeneric 12/2023 - 12/2004
50	tocilizumab (atlizumab)FDA Link 03/2024 - 09/2007
40	Antirheumatic Agents (DMARD)IBA 12/2023 - 01/2006
37	Infliximab (Remicade)FDA Link 10/2023 - 01/2005
32	GlucocorticoidsIBA 02/2024 - 02/2003
31	Adalimumab (Humira)FDA Link 11/2023 - 06/2012
30	Interleukin-6 (Interleukin 6)IBA 03/2024 - 06/2004
26	Monoclonal AntibodiesIBA 01/2023 - 10/2003
24	CytokinesIBA 01/2024 - 02/2003
24	Biomarkers (Surrogate Marker)IBA 12/2023 - 01/2009
23	Abatacept (Orencia)FDA Link 06/2023 - 03/2013
22	Etanercept (Enbrel)FDA Link 01/2023 - 12/2002
21	Immunoglobulin G (IgG)IBA 01/2023 - 01/2005
20	baricitinibIBA 01/2024 - 01/2017
20	Janus Kinase InhibitorsIBA 12/2023 - 01/2016
19	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2024 - 01/2005
15	C-Reactive ProteinIBA 02/2023 - 01/2008
14	AntibodiesIBA 03/2024 - 02/2003
14	Tumor Necrosis Factor InhibitorsIBA 11/2023 - 07/2011
14	Rituximab (Mabthera)FDA Link 11/2023 - 01/2007
13	peficitinibIBA 12/2023 - 06/2016
13	GLPG0634IBA 12/2023 - 01/2019
13	Prednisolone (Predate)FDA LinkGeneric 10/2023 - 09/2005
13	Certolizumab Pegol FDA Link 07/2023 - 07/2014
13	AutoantibodiesIBA 01/2023 - 01/2011
12	tofacitinibIBA 12/2023 - 07/2015
12	InterleukinsIBA 01/2022 - 11/2013
11	Tacrolimus (Prograf)FDA LinkGeneric 02/2024 - 02/2009
11	Janus KinasesIBA 10/2023 - 06/2017
11	Adrenal Cortex Hormones (Corticosteroids)IBA 09/2019 - 09/2005
11	EnzymesIBA 11/2018 - 01/2004
10	Proteins (Proteins, Gene)FDA Link 10/2023 - 03/2002
9	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 11/2023 - 01/2011
9	golimumab FDA Link 06/2023 - 06/2012
8	upadacitinibIBA 11/2023 - 01/2020
7	Cyclophosphamide (Cytoxan)FDA LinkGeneric 06/2023 - 09/2005
7	Messenger RNA (mRNA)IBA 06/2023 - 09/2003
7	Denosumab FDA Link 11/2021 - 06/2016
7	sirukumabIBA 01/2021 - 06/2017
7	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2020 - 01/2009
6	SteroidsIBA 10/2023 - 05/2015
6	Biosimilar PharmaceuticalsIBA 10/2023 - 06/2017
6	Sulfasalazine (Azulfidine)FDA LinkGeneric 03/2023 - 10/2013
6	omega-Chloroacetophenone (Mace)IBA 01/2023 - 01/2019
6	Leflunomide (Arava)FDA LinkGeneric 01/2023 - 01/2008
6	Immunosuppressive Agents (Immunosuppressants)IBA 11/2021 - 06/2005
6	AntigensIBA 01/2021 - 03/2004
5	sarilumabIBA 12/2023 - 06/2017
5	Rheumatoid FactorIBA 07/2023 - 01/2017
5	DNA (Deoxyribonucleic Acid)IBA 05/2023 - 06/2003
5	quetmolimabIBA 01/2023 - 01/2018
4	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 12/2023 - 01/2015
4	CT-P13IBA 10/2023 - 01/2015
4	Chemokine CX3CL1IBA 01/2023 - 01/2021
4	Peptides (Polypeptides)IBA 01/2023 - 03/2009
4	Anti-Citrullinated Protein AntibodiesIBA 01/2023 - 06/2014
4	Neutralizing AntibodiesIBA 12/2022 - 08/2003

Therapy/Procedure

97	Therapeutics 02/2024 - 08/2002
5	Biological Therapy 04/2024 - 11/2010